An autopsy case of neuronal intermediate filament inclusion disease with regard to immunophenotypic and topographical analysis of the neuronal inclusions
An autopsy case of neuronal intermediate filament An autopsy case of neuronal intermediate filament inclusion disease with regard to immunophenotypic and topographical analysis of the neuronal inclusions. Neuropathology. 2015; 35(6):545-52 (ISSN:1440-1789)
P Q R Case report A 41-year-old Japanese man first noticed his right lower limb stumbled easily. One year later, he developed gait disturbance, weakness of upper extremities, dysarthria and dysphasia. On hospital admission, 3 years after disease onset, the neurological examination disclosed spastic quadriparesis, saccadic eye movement, mood disturbance and change of personality.
Differential Dynamics of Neurofilament-H Protein and These proteins belong to the class IV intermediate filaments together with ot-internexin (Fliegner et al., 1990). Although other intermediate filaments such as vimentin and peripherin are also eed in neuronal cells during the postmitotic stage, the neurofilament triplet proteins are major intermedi-
Intermediate filaments:regulation of gene eion Eur. J. Biochem. 214, 351 -366 (1993) 0 FEBS 1993 Review Intermediate filaments :regulation of gene eion and assembly Francy A. J. M. van de KLUNDERT, Jos M. H. RAATS and Hans BLOEMENDAL Department of Biochemistry, Faculty of Science, University of Nijmegen, The Netherlands (Received January 21, 1993) - EJB 93 0099 The cytoskeleton of eukaryotic cells consists of three
Neuronal intermediate filaments and ALS:A new look at an old question Shangxi Xiao, Jesse McLean, Janice Robertson Department of Laboratory Medicine and Pathobiology, Centre for Research in Neurodegenerative Diseases, University of Toronto, Tanz Neuroscience Building, 6, Queens Park Crescent West, Toronto, ON, Canada M5S 3H2
The cytoskeleton in neurodegenerative diseasesAbundant abnormal aggregates of cytoskeletal proteins are neuropathological signatures of many neurodegenerative diseases that are broadly classified by filamentous aggregates of neuronal intermediate filament (IF) proteins, or by inclusions containing the microtubule-associated protein (MAP) tau. The discovery of mutations in neuronal IF and tau genes firmly establishes the importance of neuronal An autopsy case of neuronal intermediate filament We report an autopsy case of neuronal intermediate filament inclusion disease (NIFID), in which pyramidal motor dysfunction preceded cognitive disturbance for